The dose-response gradient here is what makes this particularly convincing. It's not an on/off switch but a clear escalation pattern as GI/GL climbs. I tried switching from white rice to brown+lentils a couple years ago and honestly the energy stability was noticeble pretty quick. What caught my attention most is how these effects compound across cardiovascular disease, diabetes-related cancers, and mortality, not just diabetes in isolation. The shared pathways (vascular dysfunction, inflammation, insulin resistance) suggest we're looking at a fundamental metabolic stress mechanism. Pairing carbs with fiber/fat/protein like you mentioned seems like such a lowhanging intervention compared to the magnitude of risk.
Such an important point about the dose–response pattern. GI/GL behaves far more like a dimmer than a switch. The metabolic load compounds as spikes become higher and more frequent. Your note on shared pathways resonates too. Once vascular dysfunction, inflammation, and insulin resistance begin overlapping, the downstream effects extend well beyond diabetes alone.
On a personal level, removing refined wheat/gluten for a period made a striking difference for me, leading to steadier energy, fewer cravings, and far less of the spike and crash cycle.
The dose-response gradient here is what makes this particularly convincing. It's not an on/off switch but a clear escalation pattern as GI/GL climbs. I tried switching from white rice to brown+lentils a couple years ago and honestly the energy stability was noticeble pretty quick. What caught my attention most is how these effects compound across cardiovascular disease, diabetes-related cancers, and mortality, not just diabetes in isolation. The shared pathways (vascular dysfunction, inflammation, insulin resistance) suggest we're looking at a fundamental metabolic stress mechanism. Pairing carbs with fiber/fat/protein like you mentioned seems like such a lowhanging intervention compared to the magnitude of risk.
Such an important point about the dose–response pattern. GI/GL behaves far more like a dimmer than a switch. The metabolic load compounds as spikes become higher and more frequent. Your note on shared pathways resonates too. Once vascular dysfunction, inflammation, and insulin resistance begin overlapping, the downstream effects extend well beyond diabetes alone.
On a personal level, removing refined wheat/gluten for a period made a striking difference for me, leading to steadier energy, fewer cravings, and far less of the spike and crash cycle.
Appreciate you adding this layer.